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Version: 17.06d (Release date: 2017-06-26)
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pan-HER Kinase Inhibitor AC480 (Code C48380)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: pan-HER Kinase Inhibitor AC480

Definition: An orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. (NCI05)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein tyrosine kinase inhibitors.

Display Name: pan-HER Kinase Inhibitor AC480

Label: pan-HER Kinase Inhibitor AC480

NCI Thesaurus Code: C48380 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541473  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AC480
BMS-599626
pan-HER Kinase Inhibitor AC480

External Source Codes: 
PDQ Closed Trial Search ID 655952
PDQ Open Trial Search ID 655952 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541473

Other Properties:
     Name Value (qualifiers indented underneath)
code C48380
Contributing_Source CTRP
Legacy_Concept_Name BMS-599626
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48380

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