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Version: 17.06d (Release date: 2017-06-26)
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Cediranib Maleate (Code C48379)

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Terms & Properties

Preferred Name: Cediranib Maleate

Definition: The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. Cediranib maleate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor.

Display Name: Cediranib Maleate

Label: Cediranib Maleate

NCI Thesaurus Code: C48379 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541530  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD2171 Maleate
Cediranib Maleate
cediranib maleate
Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-

External Source Codes: 
CAS Registry Number 857036-77-2 (see NLM ChemIDplus info)
FDA UNII Code 68AYS9A614
NSC Code 732208 (see NCI DTP info)
PDQ Closed Trial Search ID 425596
PDQ Open Trial Search ID 425596 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541530

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H27FN4O3.C4H4O4
code C48379
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name AZD2171
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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