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Version: 16.11d (Release date: 2016-11-28)
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Allogeneic GM-CSF-Secreting Breast Cancer Vaccine (Code C48371)

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Terms & Properties

Preferred Name: Allogeneic GM-CSF-Secreting Breast Cancer Vaccine

Definition: An allogenic vaccine consisting of irradiated breast cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene. Upon vaccination, the genetically modified cells secrete GM-CSF, thereby potentiating a tumor-specific T cell response against breast cancer cell-asociated antigens.

NCI-GLOSS Definition: A vaccine that is being studied as a way to help the body's immune system kill breast cancer cells. To make the vaccine, the GM-CSF gene is put into breast cancer cells in the laboratory. The cells are then treated with radiation to stop them from growing and injected into the same or a different patient. The GM-CSF protein made by the changed breast cancer cells may help the immune system kill breast cancer cells in the body.

Display Name: Allogeneic GM-CSF-Secreting Breast Cancer Vaccine

Label: Allogeneic GM-CSF-Secreting Breast Cancer Vaccine

NCI Thesaurus Code: C48371 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541366  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic GM-CSF-Secreting Breast Cancer Vaccine
GM-CSF-secreting breast tumor vaccine
GM-CSF BREAST VAC

External Source Codes: 
PDQ Closed Trial Search ID 392723
PDQ Open Trial Search ID 392723 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541366

Other Properties:
Name Value (qualifiers indented underneath)
code C48371
Contributing_Source CTRP
Legacy_Concept_Name Allogeneic_GM-CSF-Secreting_Breast_Cancer_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48371

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