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Version: 16.11d (Release date: 2016-11-28)
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AEE788 (Code C48369)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: AEE788

Definition: An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and angiogenesis inhibitors.

Label: AEE788

NCI Thesaurus Code: C48369 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1506057  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AEE-788
AEE788
AEE 788

External Source Codes: 
CAS Registry Number 497839-62-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 371727
PDQ Open Trial Search ID 371727 (check for NCI PDQ open clinical trial info)
UMLS CUI C1506057

Other Properties:
Name Value (qualifiers indented underneath)
code C48369
Legacy_Concept_Name AEE788
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48369

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