skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Estrogens, Conjugated (Code C482)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Estrogens, Conjugated

Definition: Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04)

Label: Estrogens, Conjugated

NCI Thesaurus Code: C482 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0014938  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ATC:G03CA57
Conestron
Conjugated Estrogens
Estrogens, Conjugated
ESTROGENS, CONJUGATED
Femest
Premarin
Sodestrin
Tag-39

External Source Codes: 
CAS Registry Number 12126-59-9 (see NLM ChemIDplus info)
FDA UNII Code IU5QR144QX
NSC Code 18313 (see NCI DTP info)
PDQ Closed Trial Search ID 39237
PDQ Open Trial Search ID 39237 (check for NCI PDQ open clinical trial info)
UMLS CUI C0014938

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis
code C482
Contributing_Source FDA
Legacy_Concept_Name Conjugated_Estrogens
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C482

Mainbox Bottom