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Version: 16.10e (Release date: 2016-10-31)
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Cholecalciferol (Code C48194)

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Terms & Properties

Preferred Name: Cholecalciferol

Definition: A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption.

NCI-GLOSS Definition: A nutrient that the body needs in small amounts to function and stay healthy. Cholecalciferol helps the body use calcium and phosphorus to make strong bones and teeth. It is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, egg yolks, and dairy products. Skin exposed to sunshine can also make cholecalciferol. Not enough cholecalciferol can cause a bone disease called rickets. It is being studied in the prevention and treatment of some types of cancer.

CRCH Definition: Vitamin D synthesized from ergosterol in yeast and plants.

Display Name: Cholecalciferol

Label: Cholecalciferol

NCI Thesaurus Code: C48194 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008318  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
Calciol
Cholecalciferol
CHOLECALCIFEROL
cholecalciferol
Delsterol
Vitamin D3

External Source Codes: 
CAS Registry Number 67-97-0 (see NLM ChemIDplus info)
FDA UNII Code 1C6V77QF41
ChEBI ID CHEBI:28940 (see ChEBI info)
NSC Code 375571 (see NCI DTP info)
PDQ Closed Trial Search ID 39734
PDQ Open Trial Search ID 39734 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008318

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C27H44O
code C48194
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cholecalciferol
Semantic_Type Pharmacologic Substance
Semantic_Type Vitamin
Unit mcg

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48194

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