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Version: 16.11d (Release date: 2016-11-28)
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Tetracycline Hydrochloride (Code C48020)

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Terms & Properties

Preferred Name: Tetracycline Hydrochloride

Definition: The hydrochloride salt of tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally fluorescing tetracycline binds to newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

Display Name: Tetracycline Hydrochloride

Label: Tetracycline Hydrochloride

NCI Thesaurus Code: C48020 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0546879  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
Achromycin
Tetracycline Hydrochloride
TETRACYCLINE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 64-75-5 (see NLM ChemIDplus info)
FDA UNII Code P6R62377KV
PDQ Closed Trial Search ID 42307
PDQ Open Trial Search ID 42307 (check for NCI PDQ open clinical trial info)
UMLS CUI C0546879

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H24N2O8.HCl
code C48020
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tetracycline_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48020

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