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Version: 17.06d (Release date: 2017-06-26)
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Ondansetron Hydrochloride (Code C48007)

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Terms & Properties

Preferred Name: Ondansetron Hydrochloride

Definition: The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

NCI-GLOSS Definition: The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Ondansetron Hydrochloride

Label: Ondansetron Hydrochloride

NCI Thesaurus Code: C48007 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700478  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4H-Carbazol-4-one, 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, Monohydrochloride, (+-)-, Dihydrate
GR-C507/75
GR 38032F
Ondansetron Hydrochloride
ONDANSETRON HYDROCHLORIDE
ondansetron hydrochloride
SN-307
Zofran

External Source Codes: 
CAS Registry Number 99614-01-4 (see NLM ChemIDplus info)
CAS Registry Number 103639-04-9 (see NLM ChemIDplus info)
FDA UNII Code NMH84OZK2B
NSC Code 665799 (see NCI DTP info)
PDQ Closed Trial Search ID 489533
PDQ Open Trial Search ID 489533 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700478

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative
Chemical_Formula C18H19N3O.HCl.2H2O
code C48007
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ondansetron_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48007

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