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Version: 17.08d (Release date: 2017-08-28)
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Fluphenazine Hydrochloride (Code C47995)

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Terms & Properties

Preferred Name: Fluphenazine Hydrochloride

Definition: The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting in a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin.

NCI-GLOSS Definition: A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of antipsychotic.

Display Name: Fluphenazine Hydrochloride

Label: Fluphenazine Hydrochloride

NCI Thesaurus Code: C47995 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700567  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fluphenazine Hydrochloride
fluphenazine hydrochloride

External Source Codes: 
CAS Registry Number 146-56-5 (see NLM ChemIDplus info)
NSC Code 179197 (see NCI DTP info)
PDQ Closed Trial Search ID 487523
PDQ Open Trial Search ID 487523 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700567

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H26F3N3OS.2HCl
code C47995
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluphenazine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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