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Version: 16.11d (Release date: 2016-11-28)
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Clonidine Hydrochloride (Code C47979)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Clonidine Hydrochloride

Definition: The hydrochloride salt form of clonidine, an imidazoline derivate and centrally-acting alpha-adrenergic agonist as well as antagonist with antihypertensive activity. Clonidine hydrochloride binds to and stimulates central alpha-2 adrenergic receptors, thereby decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow, leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate.

NCI-GLOSS Definition: A drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Catapres is a type of antihypertensive agent and a type of alpha-adrenergic agonist.

Label: Clonidine Hydrochloride

NCI Thesaurus Code: C47979 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0546860  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Catapres
CLONIDINE HYDROCHLORIDE
Clonidine Hydrochloride
clonidine hydrochloride

External Source Codes: 
CAS Registry Number 4205-91-8 (see NLM ChemIDplus info)
FDA UNII Code W76I6XXF06
UMLS CUI C0546860

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C9H9Cl2N3.HCl
code C47979
Contributing_Source FDA
Legacy_Concept_Name Clonidine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47979

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