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Version: 17.06d (Release date: 2017-06-26)
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Chlorhexidine Gluconate (Code C47974)

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Terms & Properties

Preferred Name: Chlorhexidine Gluconate

Definition: The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

Display Name: Chlorhexidine Gluconate

Label: Chlorhexidine Gluconate

NCI Thesaurus Code: C47974 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0055361  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Chlorhexidine Gluconate
CHLORHEXIDINE GLUCONATE

External Source Codes: 
CAS Registry Number 18472-51-0 (see NLM ChemIDplus info)
FDA UNII Code MOR84MUD8E
ChEBI ID CHEBI:28312 (see ChEBI info)
PDQ Closed Trial Search ID 747732
PDQ Open Trial Search ID 747732 (check for NCI PDQ open clinical trial info)
UMLS CUI C0055361

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H30Cl2N10.2C6H12O7
code C47974
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Chlorhexidine_Gluconate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47974

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