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Version: 17.06d (Release date: 2017-06-26)
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Cefazolin Sodium (Code C47968)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cefazolin Sodium

Definition: The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis.

Label: Cefazolin Sodium

NCI Thesaurus Code: C47968 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700526  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Sodium Salt
Ancef
CEFAZOLIN SODIUM
Cefazolin Sodium
Kefzol
SKF 41558

External Source Codes: 
CAS Registry Number 27164-46-1 (see NLM ChemIDplus info)
FDA UNII Code P380M0454Z
ChEBI ID CHEBI:3483 (see ChEBI info)
NSC Code 291561 (see NCI DTP info)
PDQ Closed Trial Search ID 640180
PDQ Open Trial Search ID 640180 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700526

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C14H13N8O4S3.Na
code C47968
Contributing_Source FDA
Legacy_Concept_Name Cefazolin_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47968

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