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Version: 17.06d (Release date: 2017-06-26)
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Azathioprine Sodium (Code C47961)

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Terms & Properties

Preferred Name: Azathioprine Sodium

Definition: The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

NCI-GLOSS Definition: A drug used to keep a patient from rejecting a transplanted kidney. It is also used in the treatment of rheumatoid arthritis that does not get better with other types of treatment. Azathioprine sodium blocks the growth of white blood cells and the synthesis of DNA, RNA, and protein. It is a type of immunosuppressant.

Label: Azathioprine Sodium

NCI Thesaurus Code: C47961 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0887732  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZATHIOPRINE SODIUM
azathioprine sodium
Azathioprine Sodium
Imuran
Imurel

External Source Codes: 
CAS Registry Number 55774-33-9 (see NLM ChemIDplus info)
FDA UNII Code AM94R510MS
NSC Code 39084 (see NCI DTP info)
PDQ Closed Trial Search ID 39157
PDQ Open Trial Search ID 39157 (check for NCI PDQ open clinical trial info)
UMLS CUI C0887732

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H6N7O2S.Na
code C47961
Contributing_Source FDA
Legacy_Concept_Name Azathioprine_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47961

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