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Version: 16.11d (Release date: 2016-11-28)
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Albuterol Sulfate (Code C47957)

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Terms & Properties

Preferred Name: Albuterol Sulfate

Definition: The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.

Display Name: Albuterol Sulfate

Label: Albuterol Sulfate

NCI Thesaurus Code: C47957 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0543495  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Albuterol Sulfate
ALBUTEROL SULFATE
Proventil
Salbutamol Sulphate
Ventolin

External Source Codes: 
CAS Registry Number 51022-70-9 (see NLM ChemIDplus info)
FDA UNII Code 021SEF3731
ChEBI ID CHEBI:2550 (see ChEBI info)
NSC Code 289928 (see NCI DTP info)
PDQ Closed Trial Search ID 41339
PDQ Open Trial Search ID 41339 (check for NCI PDQ open clinical trial info)
UMLS CUI C0543495

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula 2C13H21NO3.H2O4S
code C47957
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Albuterol_Sulfate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47957

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