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Version: 17.10e (Release date: 2017-10-30)
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Estramustine (Code C479)

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Terms & Properties

Preferred Name: Estramustine

Definition: A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)

NCI-GLOSS Definition: A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.

Label: Estramustine

NCI Thesaurus Code: C479 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0014921  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate))
estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]
Estradiol 3-[bis(2-chloroethyl)carbamate]
estradiol 3-bis(2-chloroethyl)carbamate
Leo 275
RO 21-8837

External Source Codes: 
CAS Registry Number 2998-57-4 (see NLM ChemIDplus info)
FDA UNII Code 35LT29625A
ChEBI ID CHEBI:4868 (see ChEBI info)
NSC Code 89201 (see NCI DTP info)
UMLS CUI C0014921

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Prostate Neoplasm
Chemical_Formula C23H31Cl2NO3
code C479
Contributing_Source FDA
Legacy_Concept_Name Estramustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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