Terms & Properties

Preferred Name:  Therapeutic Estradiol

Definition:  A synthetic form of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females, that may be used as hormone replacement therapy. Typically esterified, estradiol derivatives are formulated for oral, intravaginal, transdermal, or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. It may play a role in immune and inflammatory processes.

Display Name:  Therapeutic Estradiol

Label:  Therapeutic Estradiol

NCI Thesaurus Code:  C478 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  C0699359  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

(17beta)-Estra-1,3,5(10)-triene-3,17-diol

17 Beta-Estradiol

Aquadiol

Climara

Dimenformon

Diogyn

Diogynets

Estrace

ESTRADIOL

Estraldine

Oestradiol

Ovocylin

Progynon

Therapeutic Estradiol

Vagifem

External Source Codes: 

CAS Registry Number	50-28-2 (see NLM ChemIDplus info)
NCI Drug Dictionary ID	39236 (see NCI Drug Dictionary info)
FDA UNII Code	4TI98Z838E
ChEBI ID	CHEBI:16469 (see ChEBI info)
PDQ Closed Trial Search ID	39236
PDQ Open Trial Search ID	39236
UMLS CUI	C0699359

Other Properties:

Name	Value (qualifiers indented underneath)
Chemical_Formula	C18H24O2
code	C478
Contributing_Source	CTRP
Contributing_Source	FDA
Contributing_Source	GDC
Legacy Concept Name	Therapeutic_Estradiol
Maps_To	Therapeutic Estradiol
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
NSC Number	20293
NSC Number	9895
Semantic_Type	Organic Chemical
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C478