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Version: 16.11d (Release date: 2016-11-28)
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Zanamivir (Code C47786)

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Terms & Properties

Preferred Name: Zanamivir

Definition: A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication.

NCI-GLOSS Definition: A drug used to prevent and to treat influenza virus infections. It blocks the release of the virus from infected cells. It is a type of antiviral agent.

Display Name: Zanamivir

Label: Zanamivir

NCI Thesaurus Code: C47786 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0216660  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid
5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid
GANA
GG 167
Relenza
Zanamivir
ZANAMIVIR
zanamivir

External Source Codes: 
CAS Registry Number 139110-80-8 (see NLM ChemIDplus info)
FDA UNII Code L6O3XI777I
ChEBI ID CHEBI:50663 (see ChEBI info)
PDQ Closed Trial Search ID 636195
PDQ Open Trial Search ID 636195 (check for NCI PDQ open clinical trial info)
UMLS CUI C0216660

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C12H20N4O7
code C47786
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Zanamivir
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47786

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