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Version: 17.06d (Release date: 2017-06-26)
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Valsartan (Code C47781)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Valsartan

Definition: An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.

Label: Valsartan

NCI Thesaurus Code: C47781 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0216784  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CGP 48933
Diovan
L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
Valsartan
VALSARTAN

External Source Codes: 
CAS Registry Number 137862-53-4 (see NLM ChemIDplus info)
FDA UNII Code 80M03YXJ7I
ChEBI ID CHEBI:9927 (see ChEBI info)
PDQ Closed Trial Search ID 464172
PDQ Open Trial Search ID 464172 (check for NCI PDQ open clinical trial info)
UMLS CUI C0216784

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H29N5O3
code C47781
Contributing_Source FDA
Legacy_Concept_Name Valsartan
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47781

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