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Version: 17.06d (Release date: 2017-06-26)
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Tizanidine Hydrochloride (Code C47760)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tizanidine Hydrochloride

Definition: The hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors and imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects.

Display Name: Tizanidine Hydrochloride

Label: Tizanidine Hydrochloride

NCI Thesaurus Code: C47760 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771735  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, Monohydrochloride
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Hydrochloride
Tizanidine Hydrochloride
TIZANIDINE HYDROCHLORIDE
Zanaflex

External Source Codes: 
CAS Registry Number 64461-82-1 (see NLM ChemIDplus info)
FDA UNII Code B53E3NMY5C
PDQ Closed Trial Search ID 750207
PDQ Open Trial Search ID 750207 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771735

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H8ClN5S.HCl
code C47760
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tizanidine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47760

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