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Version: 17.06d (Release date: 2017-06-26)
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Tadalafil (Code C47743)

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Terms & Properties

Preferred Name: Tadalafil

Definition: A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.

NCI-GLOSS Definition: A drug used to treat erectile dysfunction. It is also being studied in the treatment of sexual problems in patients treated with radiation or surgery for prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase type 5 (PDE5) inhibitor.

Display Name: Tadalafil

Label: Tadalafil

NCI Thesaurus Code: C47743 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1176316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
Cialis
Ic351
Tadalafil
TADALAFIL
tadalafil

External Source Codes: 
CAS Registry Number 171596-29-5 (see NLM ChemIDplus info)
FDA UNII Code 742SXX0ICT
PDQ Closed Trial Search ID 462366
PDQ Open Trial Search ID 462366 (check for NCI PDQ open clinical trial info)
UMLS CUI C1176316

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Benign Prostatic Hyperplasia
Chemical_Formula C22H19N3O4
code C47743
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tadalafil
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47743

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