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Version: 16.11d (Release date: 2016-11-28)
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Sevoflurane (Code C47717)

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Terms & Properties

Preferred Name: Sevoflurane

Definition: A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate.

Label: Sevoflurane

NCI Thesaurus Code: C47717 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0074414  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-
SEVOFLURANE
Sevoflurane
Ultane

External Source Codes: 
CAS Registry Number 28523-86-6 (see NLM ChemIDplus info)
FDA UNII Code 38LVP0K73A
ChEBI ID CHEBI:9130 (see ChEBI info)
PDQ Closed Trial Search ID 524061
PDQ Open Trial Search ID 524061 (check for NCI PDQ open clinical trial info)
UMLS CUI C0074414

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C4H3F7O
code C47717
Contributing_Source FDA
Legacy_Concept_Name Sevoflurane
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47717

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