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Version: 17.06d (Release date: 2017-06-26)
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Riluzole (Code C47704)

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Terms & Properties

Preferred Name: Riluzole

Definition: A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission.

NCI-GLOSS Definition: A drug used to treat a nerve disease called amyotrophic lateral sclerosis (ALS). It is also being studied in the treatment of melanoma (a type of skin cancer). Riluzole blocks the release of a substance that melanoma cells need to grow. It is a type of glutamate release inhibitor.

Display Name: Riluzole

Label: Riluzole

NCI Thesaurus Code: C47704 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0073379  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-6-(trifluoromethoxy)benzothiazole
Rilutek
Riluzole
RILUZOLE
riluzole

External Source Codes: 
CAS Registry Number 1744-22-5 (see NLM ChemIDplus info)
FDA UNII Code 7LJ087RS6F
PDQ Closed Trial Search ID 594943
PDQ Open Trial Search ID 594943 (check for NCI PDQ open clinical trial info)
UMLS CUI C0073379

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H5F3N2OS
code C47704
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Riluzole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47704

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