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Version: 17.06d (Release date: 2017-06-26)
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Pimecrolimus (Code C47671)

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Terms & Properties

Preferred Name: Pimecrolimus

Definition: A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. However, pimecrolimus mode of action is cell-selective and does not affect Langerhans' cells/dendritic cells and primary fibroblasts.

Label: Pimecrolimus

NCI Thesaurus Code: C47671 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1099414  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
33-epi-Chloro-33-desoxyascomycin
Elidel
PIMECROLIMUS
Pimecrolimus

External Source Codes: 
CAS Registry Number 137071-32-0 (see NLM ChemIDplus info)
FDA UNII Code 7KYV510875
UMLS CUI C1099414

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C43H68ClNO11
code C47671
Contributing_Source FDA
Legacy_Concept_Name Pimecrolimus
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47671

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