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Version: 17.06d (Release date: 2017-06-26)
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Phenelzine Sulfate (Code C47668)

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Terms & Properties

Preferred Name: Phenelzine Sulfate

Definition: A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects.

Display Name: Phenelzine Sulfate

Label: Phenelzine Sulfate

NCI Thesaurus Code: C47668 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0031393  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Phenylethylhydrazine Hydrogen Sulphate
2-Phenylethylhydrazine Sulphate
Nardil
Phenelzine Sulfate
PHENELZINE SULFATE

External Source Codes: 
CAS Registry Number 156-51-4 (see NLM ChemIDplus info)
FDA UNII Code 2681D7P965
NSC Code 170957 (see NCI DTP info)
PDQ Closed Trial Search ID 686546
PDQ Open Trial Search ID 686546 (check for NCI PDQ open clinical trial info)
UMLS CUI C0031393

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H12N2.H2O4S
code C47668
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Phenelzine_Sulfate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47668

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