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Version: 16.11d (Release date: 2016-11-28)
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Perindopril Erbumine (Code C47666)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Perindopril Erbumine

Definition: The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.

Label: Perindopril Erbumine

NCI Thesaurus Code: C47666 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0244718  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Indole-2-carboxylic Acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-,(2S-(1(R*(R*))2alpha,3abeta,7abeta))-, compound with 2-Methyl-2-propanamine(1:1)
Aceon
Coversyl
MCN-A-2833-109
PERINDOPRIL ERBUMINE
Perindopril Erbumine
Perindopril Tert-butylamine
S-9490-3

External Source Codes: 
CAS Registry Number 107133-36-8 (see NLM ChemIDplus info)
FDA UNII Code 1964X464OJ
ChEBI ID CHEBI:8025 (see ChEBI info)
PDQ Closed Trial Search ID 660818
PDQ Open Trial Search ID 660818 (check for NCI PDQ open clinical trial info)
UMLS CUI C0244718

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C19H32N2O5.C4H11N
code C47666
Contributing_Source FDA
Legacy_Concept_Name Perindopril_Erbumine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47666

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