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Version: 17.06d (Release date: 2017-06-26)
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Palonosetron Hydrochloride (Code C47650)

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Terms & Properties

Preferred Name: Palonosetron Hydrochloride

Definition: The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB).

NCI-GLOSS Definition: A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Palonosetron Hydrochloride

Label: Palonosetron Hydrochloride

NCI Thesaurus Code: C47650 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1310734  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Benz(de)isoquinolin-1-one, 2-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2,3,3a,4,5,6-hexahydro-, Monohydrochloride,(3aS)-
Aloxi
Palonosetron Hydrochloride
palonosetron hydrochloride
PALONOSETRON HYDROCHLORIDE
RS 25259-197

External Source Codes: 
CAS Registry Number 135729-62-3 (see NLM ChemIDplus info)
FDA UNII Code 23310D4I19
PDQ Closed Trial Search ID 486366
PDQ Open Trial Search ID 486366 (check for NCI PDQ open clinical trial info)
UMLS CUI C1310734

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For prevention of chemotherapy-induced nausea and vomiting
Chemical_Formula C19H24N2O.HCl
code C47650
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Palonosetron_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47650

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