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Version: 17.06d (Release date: 2017-06-26)
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Oxcarbazepine (Code C47643)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oxcarbazepine

Definition: A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.

Display Name: Oxcarbazepine

Label: Oxcarbazepine

NCI Thesaurus Code: C47643 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0876196  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide
Oxcarbazepine
OXCARBAZEPINE
Trileptal

External Source Codes: 
CAS Registry Number 28721-07-5 (see NLM ChemIDplus info)
FDA UNII Code VZI5B1W380
ChEBI ID CHEBI:7824 (see ChEBI info)
PDQ Closed Trial Search ID 758784
PDQ Open Trial Search ID 758784 (check for NCI PDQ open clinical trial info)
UMLS CUI C0876196

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H12N2O2
code C47643
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Oxcarbazepine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47643

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