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Version: 17.04d (Release date: 2017-04-24)
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Olanzapine (Code C47639)

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Terms & Properties

Preferred Name: Olanzapine

Definition: A synthetic derivative of thienobenzodiazepine with antipsychotic, antinausea, and antiemetic activities. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. The antinausea and antiemetic effects of this agent appear to be due to the blockade of 5-HT2 and 5-HT3 receptors for serotonin. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through antagonism to dopamine D2 receptors with rapid ligand-receptor dissociation kinetics that help to minimize extrapyramidal symptoms (EPS). Olanzapine may also stimulate appetite.

NCI-GLOSS Definition: A drug used to treat certain mental disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antipsychotic and a type of monoamine antagonist.

Display Name: Olanzapine

Label: Olanzapine

NCI Thesaurus Code: C47639 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0171023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
LY 170053
Olanzapine
OLANZAPINE
olanzapine
Zydis
Zyprexa
Zyprexa Zydis

External Source Codes: 
CAS Registry Number 132539-06-1 (see NLM ChemIDplus info)
FDA UNII Code N7U69T4SZR
ChEBI ID CHEBI:7735 (see ChEBI info)
PDQ Closed Trial Search ID 449664
PDQ Open Trial Search ID 449664 (check for NCI PDQ open clinical trial info)
UMLS CUI C0171023

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H20N4S
code C47639
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Olanzapine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47639

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