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Version: 17.06d (Release date: 2017-06-26)
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Nesiritide (Code C47636)

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Terms & Properties

Preferred Name: Nesiritide

Definition: A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation.

Label: Nesiritide

NCI Thesaurus Code: C47636 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0054015  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative
Human Brain Natriuretic Factor-32
L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, Cyclic (10-26)-disulfide
Natriuretic factor-32
Natriuretic Peptide Type-B
Nesiritide
NESIRITIDE

External Source Codes: 
CAS Registry Number 124584-08-3 (see NLM ChemIDplus info)
FDA UNII Code P7WI8UL647
PDQ Closed Trial Search ID 434520
PDQ Open Trial Search ID 434520 (check for NCI PDQ open clinical trial info)
UMLS CUI C0054015

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C143H244N50O42S4
code C47636
Contributing_Source FDA
Legacy_Concept_Name Nesiritide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47636

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