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Version: 17.08d (Release date: 2017-08-28)
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Montelukast Sodium (Code C47625)

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Terms & Properties

Preferred Name: Montelukast Sodium

Definition: The orally bioavailable monosodium salt of montelukast, a selective cysteinyl leukotriene receptor antagonist with anti-inflammatory and bronchodilating activities. Montelukast selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory mediator leukotriene D4 (LTD4). Inhibition of LTD4 activity results in inhibition of leukotriene-mediated inflammatory events including: migration of eosinophils and neutrophils; adhesion of leukocytes to vascular endothelium, monocyte and neutrophil aggregation; increased airway edema; increased capillary permeability; and bronchoconstriction. The CysLT1 receptor is found in a number of tissues including spleen, lung, placenta, small intestine, and nasal mucosa, and in a variety of cell types including monocyte/macrophages, mast cells, eosinophils, CD34-positive hemopoietic progenitor cells, neutrophils and endothelial cells.

NCI-GLOSS Definition: A drug used to treat symptoms of asthma, such as trouble breathing, tight chest, wheezing, coughing, and runny nose. Montelukast sodium blocks the action of a substance that causes airways in the lungs to narrow and causes other symptoms of asthma. It is a type of leukotriene receptor antagonist and a type of antiasthmatic agent.

Display Name: Montelukast Sodium

Label: Montelukast Sodium

NCI Thesaurus Code: C47625 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0380447  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cyclopropaneacetic Acid, 1-((((1R)-1-(3-((1E)-2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-, Monosodium Salt
MK 476
Montelukast Sodium
montelukast sodium

External Source Codes: 
CAS Registry Number 151767-02-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:6993 (see ChEBI info)
PDQ Closed Trial Search ID 593502
PDQ Open Trial Search ID 593502 (check for NCI PDQ open clinical trial info)
UMLS CUI C0380447

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C35H35ClNO3S.Na
code C47625
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Montelukast_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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