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Version: 17.06d (Release date: 2017-06-26)
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Minocycline Hydrochloride (Code C47622)

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Terms & Properties

Preferred Name: Minocycline Hydrochloride

Definition: The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.

Display Name: Minocycline Hydrochloride

Label: Minocycline Hydrochloride

NCI Thesaurus Code: C47622 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0026186  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
Dynacin
Minocin
Minocycline Hydrochloride
MINOCYCLINE HYDROCHLORIDE
Minomax
Minomycin
Tri-minocycline
Vectrin

External Source Codes: 
CAS Registry Number 13614-98-7 (see NLM ChemIDplus info)
FDA UNII Code 0020414E5U
ChEBI ID CHEBI:50697 (see ChEBI info)
NSC Code 141993 (see NCI DTP info)
PDQ Closed Trial Search ID 552699
PDQ Open Trial Search ID 552699 (check for NCI PDQ open clinical trial info)
UMLS CUI C0026186

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H27N3O7.HCl
code C47622
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Minocycline_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47622

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