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Version: 17.06d (Release date: 2017-06-26)
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Memantine Hydrochloride (Code C47601)

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Terms & Properties

Preferred Name: Memantine Hydrochloride

Definition: The hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist.

NCI-GLOSS Definition: A drug used to treat dementia caused by Alzheimer disease. It is also being studied in the treatment of side effects from whole-brain radiation therapy for cancer and other conditions. Memantine hydrochloride blocks the uptake of calcium by certain brain cells and decreases their activity. It is a type of N-methyl-D-asparatate (NMDA) receptor antagonist.

Display Name: Memantine Hydrochloride

Label: Memantine Hydrochloride

NCI Thesaurus Code: C47601 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771988  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-amino-3,5-dimethyladamantane Hydrochloride
Memantine Hydrochloride
memantine hydrochloride

External Source Codes: 
CAS Registry Number 41100-52-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:64323 (see ChEBI info)
NSC Code 102290 (see NCI DTP info)
PDQ Closed Trial Search ID 579596
PDQ Open Trial Search ID 579596 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771988

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H21N.HCl
code C47601
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Memantine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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