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Version: 17.06d (Release date: 2017-06-26)
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Mebendazole (Code C47595)

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Terms & Properties

Preferred Name: Mebendazole

Definition: A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.

Display Name: Mebendazole

Label: Mebendazole

NCI Thesaurus Code: C47595 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester
Mebendazole
MEBENDAZOLE
Methyl 5-benzoyl benzimidazole-2-carbamate
R 17635
Vermox

External Source Codes: 
CAS Registry Number 31431-39-7 (see NLM ChemIDplus info)
FDA UNII Code 81G6I5V05I
ChEBI ID CHEBI:6704 (see ChEBI info)
NSC Code 184849 (see NCI DTP info)
PDQ Closed Trial Search ID 743306
PDQ Open Trial Search ID 743306 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025023

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H13N3O3
code C47595
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mebendazole
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47595

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