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Version: 16.11d (Release date: 2016-11-28)
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Levonorgestrel (Code C47585)

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Terms & Properties

Preferred Name: Levonorgestrel

Definition: The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.

NCI-GLOSS Definition: A form of the hormone progesterone that is made in the laboratory and used to prevent pregnancy. It is being studied in the prevention of ovarian and endometrial cancer, and in the treatment of other conditions. Levonorgestrel is a type of oral contraceptive.

Display Name: Levonorgestrel

Label: Levonorgestrel

NCI Thesaurus Code: C47585 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0023566  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one
18-Methylnorethisterone
D-(-)-Norgestrel
L-norgestrel
Levonorgestrel
LEVONORGESTREL
levonorgestrel
Mirena
Norplant
Plan B

External Source Codes: 
CAS Registry Number 797-63-7 (see NLM ChemIDplus info)
FDA UNII Code 5W7SIA7YZW
ChEBI ID CHEBI:6443 (see ChEBI info)
PDQ Closed Trial Search ID 534399
PDQ Open Trial Search ID 534399 (check for NCI PDQ open clinical trial info)
UMLS CUI C0023566

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C21H28O2
code C47585
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Levonorgestrel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47585

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