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Version: 16.10e (Release date: 2016-10-31)
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Levetiracetam (Code C47581)

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Terms & Properties

Preferred Name: Levetiracetam

Definition: A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.

NCI-GLOSS Definition: A drug used to treat seizures (involuntary muscle movements) caused by epilepsy (a group of brain disorders). Keppra is being studied in the treatment of seizures in patients with cancer that has spread to the brain. It is a type of anticonvulsant.

Label: Levetiracetam

NCI Thesaurus Code: C47581 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0377265  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide
1-Pyrrolidineacetamide, Alpha-ethyl-2-oxo-,(S)-
Keppra
LEVETIRACETAM
Levetiracetam
levetiracetam

External Source Codes: 
CAS Registry Number 102767-28-2 (see NLM ChemIDplus info)
FDA UNII Code 44YRR34555
ChEBI ID CHEBI:6437 (see ChEBI info)
PDQ Closed Trial Search ID 526173
PDQ Open Trial Search ID 526173 (check for NCI PDQ open clinical trial info)
UMLS CUI C0377265

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Treating partial-onset seizures in patients with epilepsy.
Chemical_Formula C8H14N2O2
code C47581
Contributing_Source FDA
Legacy_Concept_Name Levetiracetam
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47581

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