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Version: 17.06d (Release date: 2017-06-26)
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Galantamine Hydrobromide (Code C47546)

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Terms & Properties

Preferred Name: Galantamine Hydrobromide

Definition: The hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse.

Label: Galantamine Hydrobromide

NCI Thesaurus Code: C47546 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0949312  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, Hydrobromide
GALANTAMINE HYDROBROMIDE
Galantamine Hydrobromide
Lycoremine Hydrobromide
Nivalin
Razadyne
Reminyl

External Source Codes: 
CAS Registry Number 1953-04-4 (see NLM ChemIDplus info)
CAS Registry Number 69353-21-5 (see NLM ChemIDplus info)
FDA UNII Code MJ4PTD2VVW
PDQ Closed Trial Search ID 739214
PDQ Open Trial Search ID 739214 (check for NCI PDQ open clinical trial info)
UMLS CUI C0949312

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H21NO3.BrH
code C47546
Contributing_Source FDA
Legacy_Concept_Name Galantamine_Hydrobromide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47546

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