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Version: 17.06d (Release date: 2017-06-26)
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Fosfomycin Tromethamine (Code C47541)

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Terms & Properties

Preferred Name: Fosfomycin Tromethamine

Definition: The tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05)

Label: Fosfomycin Tromethamine

NCI Thesaurus Code: C47541 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0543454  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1)
Fosfomycin compound with Trometamol
Fosfomycin Trometamol Salt
Fosfomycin Tromethamine
FOSFOMYCIN TROMETHAMINE
Monurol

External Source Codes: 
CAS Registry Number 78964-85-9 (see NLM ChemIDplus info)
FDA UNII Code 7FXW6U30GY
UMLS CUI C0543454

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C4H11NO3.C3H7O4P
code C47541
Contributing_Source FDA
Legacy_Concept_Name Fosfomycin_Tromethamine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47541

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