skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Ethosuximide (Code C47523)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ethosuximide

Definition: A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures.

Label: Ethosuximide

NCI Thesaurus Code: C47523 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0015043  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Ethyl-3-methylpyrrolidine-2,5-dione
ETHOSUXIMIDE
Ethosuximide
Zarontin

External Source Codes: 
CAS Registry Number 77-67-8 (see NLM ChemIDplus info)
FDA UNII Code 5SEH9X1D1D
ChEBI ID CHEBI:4887 (see ChEBI info)
NSC Code 64013 (see NCI DTP info)
UMLS CUI C0015043

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H11NO2
code C47523
Contributing_Source FDA
Legacy_Concept_Name Ethosuximide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47523

Mainbox Bottom