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Version: 17.06d (Release date: 2017-06-26)
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Eplerenone (Code C47513)

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Terms & Properties

Preferred Name: Eplerenone

Definition: A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.

Label: Eplerenone

NCI Thesaurus Code: C47513 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0961485  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester

External Source Codes: 
CAS Registry Number 107724-20-9 (see NLM ChemIDplus info)
FDA UNII Code 6995V82D0B
ChEBI ID CHEBI:31547 (see ChEBI info)
UMLS CUI C0961485

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H30O6
code C47513
Contributing_Source FDA
Legacy_Concept_Name Eplerenone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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