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Version: 17.06d (Release date: 2017-06-26)
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Emtricitabine (Code C47509)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Emtricitabine

Definition: A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group).

Display Name: Emtricitabine

Label: Emtricitabine

NCI Thesaurus Code: C47509 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0909839  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-2'-Deoxy-5-fluoro-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-
BW-524W91
Coviracil
dOTFC
Emtricitabine
EMTRICITABINE
Emtriva
FTC

External Source Codes: 
CAS Registry Number 143491-57-0 (see NLM ChemIDplus info)
FDA UNII Code G70B4ETF4S
ChEBI ID CHEBI:31536 (see ChEBI info)
PDQ Closed Trial Search ID 540668
PDQ Open Trial Search ID 540668 (check for NCI PDQ open clinical trial info)
UMLS CUI C0909839

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H10FN3O3S
code C47509
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Emtricitabine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47509

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