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Version: 16.10e (Release date: 2016-10-31)
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Dutasteride (Code C47503)

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Terms & Properties

Preferred Name: Dutasteride

Definition: A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

NCI-GLOSS Definition: A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor.

Display Name: Dutasteride

Label: Dutasteride

NCI Thesaurus Code: C47503 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0754659  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
Avodart
Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Dutasteride
DUTASTERIDE
dutasteride
GG745
GG 745

External Source Codes: 
CAS Registry Number 164656-23-9 (see NLM ChemIDplus info)
FDA UNII Code O0J6XJN02I
ChEBI ID CHEBI:521033 (see ChEBI info)
PDQ Closed Trial Search ID 479183
PDQ Open Trial Search ID 479183 (check for NCI PDQ open clinical trial info)
UMLS CUI C0754659

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C27H30F6N2O2
code C47503
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dutasteride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47503

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