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Version: 17.06d (Release date: 2017-06-26)
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Diflunisal (Code C47489)

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Terms & Properties

Preferred Name: Diflunisal

Definition: A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.

Display Name: Diflunisal

Label: Diflunisal

NCI Thesaurus Code: C47489 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012228  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-
2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid
Apo-Diflunisal
Diflunisal
DIFLUNISAL
Dolobid
Flovacil
Novo-Diflunisal
Nu-Diflunisal

External Source Codes: 
CAS Registry Number 22494-42-4 (see NLM ChemIDplus info)
FDA UNII Code 7C546U4DEN
ChEBI ID CHEBI:39669 (see ChEBI info)
PDQ Closed Trial Search ID 691337
PDQ Open Trial Search ID 691337 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012228

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H8F2O3
code C47489
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Diflunisal
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47489

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