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Version: 17.06d (Release date: 2017-06-26)
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Desogestrel (Code C47476)

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Terms & Properties

Preferred Name: Desogestrel

Definition: A synthetic progestogen structurally related to levonorgestrel, with progesterone hormone receptor agonistic activity, used as a contraceptive and hormone replacement agent. Upon administration, desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA causing either gene transcription or gene repression. This eventually leads to an inhibition of gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and a subsequent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This prevents ovulation and alters the cervical mucus.

Label: Desogestrel

NCI Thesaurus Code: C47476 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0057558  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
Cerazette
Desogestrel
DESOGESTREL

External Source Codes: 
CAS Registry Number 54024-22-5 (see NLM ChemIDplus info)
FDA UNII Code 81K9V7M3A3
ChEBI ID CHEBI:4453 (see ChEBI info)
PDQ Closed Trial Search ID 743774
PDQ Open Trial Search ID 743774 (check for NCI PDQ open clinical trial info)
UMLS CUI C0057558

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H30O
code C47476
Contributing_Source FDA
Legacy_Concept_Name Desogestrel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47476

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