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Version: 17.06d (Release date: 2017-06-26)
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Daptomycin (Code C47470)

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Terms & Properties

Preferred Name: Daptomycin

Definition: A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria.

NCI-GLOSS Definition: A drug used to treat certain bacterial skin and bloodstream infections in adults. Cubicin is also being studied in the treatment of fever and neutropenia (an abnormal decrease in the number of neutrophils, a type of white blood cell) in patients with cancer. It is a type of antibiotic.

Display Name: Daptomycin

Label: Daptomycin

NCI Thesaurus Code: C47470 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0057144  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cubicin
Daptomycin
DAPTOMYCIN
daptomycin
LY146032
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone

External Source Codes: 
CAS Registry Number 103060-53-3 (see NLM ChemIDplus info)
FDA UNII Code NWQ5N31VKK
ChEBI ID CHEBI:600103 (see ChEBI info)
PDQ Closed Trial Search ID 469015
PDQ Open Trial Search ID 469015 (check for NCI PDQ open clinical trial info)
UMLS CUI C0057144

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C72H101N17O26
code C47470
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Daptomycin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47470

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