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Version: 17.06d (Release date: 2017-06-26)
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Cycloserine (Code C47466)

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Terms & Properties

Preferred Name: Cycloserine

Definition: An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.

NCI-GLOSS Definition: A drug used to treat tuberculosis. It is also being studied in the treatment of pain and nerve problems (numbness, tingling) caused by chemotherapy and in the treatment of low back pain, autism, certain anxiety disorders, and schizophrenia. D-cycloserine is a type of antibiotic.

Label: Cycloserine

NCI Thesaurus Code: C47466 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0010590  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+)-4-Amino-3-isoxazolidinone
3-Isoxazolidinone, 4-amino-, d-
Cycloserine
CYCLOSERINE
D-Cycloserine
D-cycloserine
Oxamycin
Seromycin
Tisomycin

External Source Codes: 
CAS Registry Number 68-41-7 (see NLM ChemIDplus info)
FDA UNII Code 95IK5KI84Z
ChEBI ID CHEBI:40009 (see ChEBI info)
NSC Code 154851 (see NCI DTP info)
PDQ Closed Trial Search ID 469006
PDQ Open Trial Search ID 469006 (check for NCI PDQ open clinical trial info)
UMLS CUI C0010590

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C3H6N2O2
code C47466
Contributing_Source FDA
Legacy_Concept_Name Cycloserine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47466

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