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Version: 17.06d (Release date: 2017-06-26)
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Cyclobenzaprine Hydrochloride (Code C47465)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cyclobenzaprine Hydrochloride

Definition: A centrally acting muscle relaxant, chemically similar to amitriptyline hydrochloride with antidepressant activity. The exact mechanism of action of cyclobenzaprine hydrochloride has not been fully determined. However, it primarily acts at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons. This leads to a reduction in muscle spasms.

Display Name: Cyclobenzaprine Hydrochloride

Label: Cyclobenzaprine Hydrochloride

NCI Thesaurus Code: C47465 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0125988  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, Hydrochloride
10,11delta-Amitriptyline Hydrochloride
3-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)propyl(dimethyl)ammonium Chloride
Cloben
Cyclobenzaprine Hydrochloride
CYCLOBENZAPRINE HYDROCHLORIDE
Cycloflex
Flexeril
Flexiban
FR2100873
Novo-Cycloprine

External Source Codes: 
CAS Registry Number 6202-23-9 (see NLM ChemIDplus info)
FDA UNII Code 0VE05JYS2P
ChEBI ID CHEBI:3997 (see ChEBI info)
NSC Code 78206 (see NCI DTP info)
NSC Code 169900 (see NCI DTP info)
NSC Code 173379 (see NCI DTP info)
PDQ Closed Trial Search ID 751769
PDQ Open Trial Search ID 751769 (check for NCI PDQ open clinical trial info)
UMLS CUI C0125988

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H21N.HCl
code C47465
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cyclobenzaprine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47465

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