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Version: 16.10e (Release date: 2016-10-31)
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Cinacalcet Hydrochloride (Code C47450)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cinacalcet Hydrochloride

Definition: The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.

Display Name: Cinacalcet Hydrochloride

Label: Cinacalcet Hydrochloride

NCI Thesaurus Code: C47450 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1260199  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride
Cinacalcet Hydrochloride
CINACALCET HYDROCHLORIDE
Mimpara
Sensipar

External Source Codes: 
CAS Registry Number 364782-34-3 (see NLM ChemIDplus info)
FDA UNII Code 1K860WSG25
ChEBI ID CHEBI:48391 (see ChEBI info)
PDQ Closed Trial Search ID 662071
PDQ Open Trial Search ID 662071 (check for NCI PDQ open clinical trial info)
UMLS CUI C1260199

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H22F3N.HCl
code C47450
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cinacalcet_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47450

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