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Version: 17.06d (Release date: 2017-06-26)
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Cabergoline (Code C47428)

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Terms & Properties

Preferred Name: Cabergoline

Definition: A synthetic ergoline derivative and a long-acting dopamine receptor agonist with high affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on prolactin secretion by acting on dopamine receptors present in pituitary lactotrophs. This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. Cabergoline also possesses antioxidant and neuroprotective properties due to its free radical scavenging activity. Cabergoline is used in the treatment of Parkinson's disease and in the treatment of hyperprolactinemia.

Display Name: Cabergoline

Label: Cabergoline

NCI Thesaurus Code: C47428 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0107994  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
Cabergoline
CABERGOLINE
Dostinex
FCE 21336

External Source Codes: 
CAS Registry Number 81409-90-7 (see NLM ChemIDplus info)
FDA UNII Code LL60K9J05T
ChEBI ID CHEBI:3286 (see ChEBI info)
PDQ Closed Trial Search ID 680438
PDQ Open Trial Search ID 680438 (check for NCI PDQ open clinical trial info)
UMLS CUI C0107994

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H37N5O2
code C47428
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cabergoline
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47428

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