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Version: 17.06d (Release date: 2017-06-26)
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Epirubicin Hydrochloride (Code C474)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Epirubicin Hydrochloride

Definition: The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.

NCI-GLOSS Definition: A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Ellence is a type of anthracycline antibiotic.

Display Name: Epirubicin Hydrochloride

Label: Epirubicin Hydrochloride

NCI Thesaurus Code: C474 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700582  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside Hydrochloride
Ellence
Epirubicin Hydrochloride
epirubicin hydrochloride
EPIRUBICIN HYDROCHLORIDE
IMI-28
Pharmorubicin PFS

External Source Codes: 
CAS Registry Number 56390-09-1 (see NLM ChemIDplus info)
FDA UNII Code 22966TX7J5
NSC Code 256942 (see NCI DTP info)
PDQ Closed Trial Search ID 39232
PDQ Open Trial Search ID 39232 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700582

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer
Chemical_Formula C27H29NO11.HCl
code C474
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Epirubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C474

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