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Version: 17.06d (Release date: 2017-06-26)
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Aminophylline (Code C47393)

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Terms & Properties

Preferred Name: Aminophylline

Definition: A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.

Display Name: Aminophylline

Label: Aminophylline

NCI Thesaurus Code: C47393 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0002575  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1)
Aminophylline
AMINOPHYLLINE
Ammophyllin
Phyllocontin
Theophyline Ethylenediamine
Truphylline

External Source Codes: 
CAS Registry Number 317-34-0 (see NLM ChemIDplus info)
FDA UNII Code 27Y3KJK423
NSC Code 7919 (see NCI DTP info)
PDQ Closed Trial Search ID 682624
PDQ Open Trial Search ID 682624 (check for NCI PDQ open clinical trial info)
UMLS CUI C0002575

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C7H8N4O2.C2H8N2
code C47393
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Aminophylline
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47393

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